Case 1: Acids/Bases/Buffers

Readings:

Review

• http://www.botany.uwc.ac.za/mirrors/MIT-bio/bio/chem/review.html

Background

• http://www.med.unibs.it/~marchesi/ionicrev.html

read only these sections (others are not necessary) of the above site:

Definition of Keq, Kw and pH

Definition of pKa

The Henderson-Hasselbalch Equation

Definition of Buffering

Significance of Blood Buffering

Ampholyte, Polyampholyte, pI and Zwitterion

Definition of Solvation and Hydration

• http://cti.itc.virginia.edu/~cmg/Demo/titr.html (titration of amino acids)

Specific to Aspirin Case

• http://www.aspirin-foundation.com/chemist.htm
• http://www.bris.ac.uk/Depts/Chemistry/MOTM/aspirin/aspirin.htm

Calendar (with preliminary due dates)

LabStuff:

Pre-Lab: Read this

http://ntri.tamuk.edu/fplc/prep.html

Essentials (what you should know/be able to do when the case is over):

• Recognize and predict non-covalent interactions in molecules
• Use the H-H equation
• Draw and interpret titration curves
• Use table of pKa values to choose an appropriate buffer system
• Make a buffer!